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This lecture covers the design of a neuromodulation system for deep brain stimulation, including a frontend IC and a DSP IC. It focuses on a chopper-stabilized capacitive-coupled instrumentation amplifier, a BrainForest classifier, and a neuromodulation SoC with an 8-channel noise-shaping SAR ADC array. The system aims to accurately determine the optimal moment for neuromodulation efficacy, such as before the onset of a seizure in epilepsy, and supports closed-loop neuromodulation through an on-chip electrical neurostimulator.