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This lecture by the instructor covers the development of cameras optimized for machine learning tasks and the use of machine learning to enhance camera capabilities. Topics include physics-informed machine learning for lensless imaging, deep learning for imaging inverse problems, and the application of algorithms to solve imaging challenges. The lecture explores the optimization of cameras for high-resolution images, the use of deep learning for spatially-varying microscopy, and the training of denoisers using synthetic noisy videos. Additionally, it delves into the creation of noise models for low-light videos, the simulation of supervised denoising, and the advancement of computational cameras through physics-informed machine learning. The presentation showcases the instructor's work on pushing the limits of cameras with GAN-tuned noise models and the achievement of photorealistic videography in low-light conditions.