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This lecture explores the functions and interactions of glial cells in the nervous system. It covers the different types of glia cells, such as astrocytes, oligodendrocytes, microglia, and ependymal cells, detailing their roles in supporting neurons, myelination, synaptic transmission, and memory formation. The lecture also discusses the blood-brain barrier, demyelinating diseases like Multiple Sclerosis, and the reprogramming of NG2 glia in response to injuries. Additionally, it delves into the role of oligodendrocyte precursor cells in myelin plasticity and memory consolidation, shedding light on their potential for neuronal replacement therapies.