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This lecture introduces Analysis of Variance (ANOVA) as a statistical method to compare means of multiple groups simultaneously. Starting with the limitations of using multiple t-tests, it explains the importance of ANOVA in evaluating mean differences efficiently. The lecture covers the ANOVA table generation, degrees of freedom, sum of squares, mean squares, F value, and methodology. An example of blood coagulation based on diet illustrates ANOVA in practice. It also discusses the interpretation of F-ratio values and the need for post tests to identify specific treatment differences. The lecture concludes with extensions to ANOVA, pitfalls in significance testing, and guidelines for interpreting F-ratio values.