Lecture
This lecture covers the concepts of thermodynamics and chromatography, focusing on the modeling and modification of the caprim retention factor. It explains how changing caprim involves adjusting the distribution constant, which is a thermodynamic constant dependent on temperature. The lecture also discusses the relationship between retention time and distribution constant in planar chromatography, emphasizing the impact of polarity on mobile and stationary phases. Additionally, it explores the equilibrium constant and the factors influencing the chemical potential in chromatography, highlighting the role of solvent polarity in altering the equilibrium. The lecture concludes with a detailed explanation of the equilibrium constant and its implications on species retention in chromatography.