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This lecture explores the impact of burnup on neutronics in nuclear reactors, focusing on the evolution of fissioning isotopes, such as uranium and plutonium, with respect to burnup. It delves into the production mechanisms of Pu-239 from U-238, the moderation effects on plutonium production, and the implications of fission product poisons like Xe-135 and Sm-149. The lecture also covers the concept of Xenon Equilibrium, the reactivity insertion due to Xe-135 buildup, and the role of internal coolant circulation in BWRs. Additionally, it discusses steam drying mechanisms, cyclone separators, and the summary of nuclear fuel irradiation effects on reactor safety parameters.