Post-Translational Modifications and Folding in the ER

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Explores protein structure analysis, folding, modifications, and their impact on diseases and protein activity regulation.

Provides an overview of translation and protein synthesis, covering the genetic code, tRNA, and the steps involved in protein formation.

Explores single-molecule studies of the Hsp90 chaperone and protein function using optical tweezers.

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Explores the genetic basis of J-domain protein specificity and the essential role of Sis1 in protein homeostasis.

Explores protein folding dynamics, focusing on chaperone-assisted non-equilibrium stabilization and its implications for biophysics and evolution.

Covers protein folding, maturation, degradation, and the implications of misfolding in neurodegenerative diseases.

Explores protein folding forces, including van der Waals interactions, hydrogen bonds, and salt bridges, and their impact on stability.

Explores chaperones' role in guiding protein folding and preventing misfolding through the functional cycle of Hsp70 and the DnaK chaperone system.

Explores AMPylation's role in cellular communication and neurodegeneration, with potential implications for Parkinson's Disease.