Telomeres and Cancer

In course

Description

This lecture covers the role of telomeres in cancer biology, focusing on telomerase, telomere replication problems, and the alternative lengthening of telomeres (ALT) pathway. It discusses the historical perspective, telomere function, end replication problems, telomerase reaction cycle, telomeric DNA, and the Nobel Prize-winning discovery of telomeres protection. The lecture also explores the end replication problem solutions, telomere maintenance mechanisms, and the impact of telomeres on cellular senescence and tumorigenesis.

Instructors (2)

Official source

https://mediaspace.epfl.ch/media/0_dt0fjzih

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Related lectures (23)

Related concepts (159)

Telomerase

Telomerase, also called terminal transferase, is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring chromosomes. The fruit fly Drosophila melanogaster lacks telomerase, but instead uses retrotransposons to maintain telomeres. Telomerase is a reverse transcriptase enzyme that carries its own RNA molecule (e.

Telomere

A telomere (ˈtɛləmɪər,_ˈtiːlə-; ) is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes. Telomeres are a widespread genetic feature most commonly found in eukaryotes. In most, if not all species possessing them, they protect the terminal regions of chromosomal DNA from progressive degradation and ensure the integrity of linear chromosomes by preventing DNA repair systems from mistaking the very ends of the DNA strand for a double-strand break.

DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule. DNA replication occurs in all living organisms acting as the most essential part of biological inheritance. This is essential for cell division during growth and repair of damaged tissues, while it also ensures that each of the new cells receives its own copy of the DNA. The cell possesses the distinctive property of division, which makes replication of DNA essential.

Cellular senescence

Cellular senescence is a phenomenon characterized by the cessation of cell division. In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent. This process is known as "replicative senescence", or the Hayflick limit. Hayflick's discovery of mortal cells paved the path for the discovery and understanding of cellular aging molecular pathways.

Nobel Prize

The Nobel Prizes (noʊˈbɛl ; Nobelpriset nʊˈbɛ̂lːˌpriːsɛt; Nobelprisen nʊˈbɛ̀lːˌpriːsn̩) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfred Nobel was a Swedish chemist, engineer, and industrialist most famously known for the invention of dynamite. He died in 1896. In his will, he bequeathed all of his "remaining realisable assets" to be used to establish five prizes which became known as "Nobel Prizes.