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This lecture introduces simple models for understanding complex biological phenomena, covering mechanics, information, and chemistry. It explores the physical models used to study DNA packing, E. coli modeling, cell membrane structure, and the sizes of life's molecules. The comparison between mRNA and protein sizes, the speed of DNA replication, ribosome counting, and the genome size of bacteria and archaea are also discussed. The lecture delves into the energy aspects of biological processes, the computation of KT, and the renewal rates of various cell types, providing insights into the fundamental numerical aspects of biology.