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This lecture covers the fundamental aspects of anion recognition, focusing on the differences between anions and cations, the geometry of anion receptors, and specific examples of anion binding molecules such as phosphate binding proteins and hydrogen-bond receptors. The instructor discusses the challenges of anion recognition due to the larger size and higher solvation energy of anions compared to cations, emphasizing the importance of matching the receptor's geometry to that of the anion for effective binding.