This lecture introduces the concept of simulation in biophysics, focusing on the types of simulations, their applications, and the considerations involved in choosing the appropriate simulation type for a given soft matter problem. It covers the anatomy of a simulation, including setting up the system, defining initial and boundary conditions, interactions, integration schemes, and observables. The lecture also discusses the impact of initial conditions, the importance of precision and error analysis in simulations, and the pros and cons of using simulations in scientific research.