Lecture

Macromolecular Crystallography: Techniques and Applications

Description

This lecture covers the techniques and applications of synchrotrons and x-ray free-electron lasers in macromolecular crystallography. The instructor explains the phase problem for large molecules, detailing approaches like multiple isomorphous replacement, multiwavelength anomalous dispersion, and single-wavelength anomalous diffraction. Various macromolecular crystallography approaches are discussed, including Multiple/Single Isomorphous Replacement, Multiwavelength Anomalous Dispersion, and Single-Wavelength Anomalous Diffraction. The lecture also explores trends in MX phasing techniques, such as MIR, SIR, and MAD. Practical examples like the COVID-19 main protease and Benzylpenicillin are used to illustrate the concepts.

In MOOCs (2)
Synchrotrons and X-Ray Free Electron Lasers (part 1)
Synchrotrons and X-Ray Free Electron Lasers (part 1)
Synchrotrons and X-Ray Free Electron Lasers (part 2)
The first MOOC to provide an extensive introduction to synchrotron and XFEL facilities and associated techniques and applications.
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