This lecture covers the fundamentals of motor neuroprosthetics, focusing on the peripheral nervous system. Topics include causes of amputation, upper and lower limb amputations, motor decoding using EMG signals, robotic prosthetic hands, targeted muscle reinnervation, osseointegration, sensory feedback, and advanced motor decoding techniques. The instructor discusses the challenges and advancements in improving control and sensory feedback for prosthetic limbs, emphasizing the importance of stable signals and reliable decoding. Various assessment approaches for evaluating motor function and cognitive load are also explored.