Generation of Enantiopure Compounds

This lecture covers the generation of enantiopure compounds through the use of chiral catalysts, desymmetrization, and resolution of racemic mixtures. Various methods for synthesizing enantio-enriched compounds are discussed, along with the importance of enantiomer separation. The concept of kinetic resolution and the formation of diastereomers for enantiopure compound synthesis are also explained. Additionally, the lecture delves into conformational analysis, stereoelectronic effects, and the energy considerations in different conformations. Special interactions in molecules like pentane are highlighted, along with the destabilization effects in discodermolide. The significance of allylic tension in propene and the energy differences in eclipsed conformations are also explored.