Nicotinic Receptors: Structure and Function

This lecture delves into the structure and function of nicotinic receptors, focusing on Cys-loop receptors and their homologous proteins. The instructor discusses the modular domain design of these receptors, the gating and ion conductance of the channel, and the single-channel conductance properties. The lecture also covers the agonist-dependent and agonist-independent kinetics of the receptors, as well as the mechanisms of activation and inactivation. Furthermore, the effects of nicotine on the receptors, including up-regulation and modulation, are explored. Various experiments and models are presented to illustrate the intricate workings of nicotinic receptors.