Antigen Receptor Generation: Somatic Recombination and Diversity

This lecture covers the generation of B and T cell receptors through somatic recombination, focusing on the rearrangement of gene segments V, D, and J, the organization of the antigen receptor locus, and the mechanisms behind combinatorial and junctional diversity. The process involves DNA digestion, isolation, electrophoresis, and hybridization, leading to the formation of a diverse repertoire of antigen receptors.