Protein Aggregation Kinetics and Drug Discovery

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Proteome Foldedness & Aggregation: Surveying Proteostasis Stress

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Non-cell Autonomous Mechanisms: SOD1 Pathology

Explores the mechanisms of ALS, focusing on SOD1 pathology, including toxic gain of function, protein misfolding, ER stress, and mitochondrial dysfunction.

Computational Protein Design: Principles and Challenges

Covers the principles and challenges of computational protein design in bioengineering.

Protein Aggregation and Disaggregation: Insights from In Vivo Studies

Explores protein aggregation and disaggregation mechanisms, focusing on huntingtin protein in Huntington's Disease.

Molecular Mechanism of Chaperonin GroEL

Explores the molecular mechanism and client preference of chaperonin GroEL in protein folding and aggregation prevention.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Protein-Ligand Interactions: Importance and Affinity

Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.

Protein Fibrillar Aggregation

Explores cryo-EM techniques for studying protein aggregation in neurodegenerative diseases, focusing on a-synuclein.

The ClpXP Proteolytic Complex: Basic Principles to Drug Discovery

Explores the ClpXP proteolytic complex, its drug targeting potential, and antimicrobial applications through compound screening.

Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.