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This lecture explores the field of data science in personalized and global health, focusing on advanced privacy-enhancing technologies. Dr. Jean Louis Raisaro discusses the multidisciplinary nature of data science, the importance of health data modalities, and the applications of artificial intelligence in healthcare. The lecture covers topics such as data preparation, model training, and the implementation of AI in medicine. It also addresses key issues like data sharing, privacy, and the use of advanced privacy-enhancing technologies to protect aggregate data output. The presentation concludes with a discussion on the legal compliance and the future of privacy-preserving AI in medicine.