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This lecture covers the principles of nuclear engineering, focusing on safety systems, reactor protection, and the containment of radioactive materials. It discusses reactor technology, decay heat, spent fuel components, physicochemical properties, and barriers against radioactive material release. The instructor explains the safety goals related to reactivity control, fuel cooling, and radioactivity confinement. Various accidents scenarios, safety analyses, and the importance of safety margins are also addressed, emphasizing the probabilistic safety analyses to prevent core damage. The lecture concludes with a detailed explanation of design base accidents, safety system failures, and the regulatory requirements for maintaining safety margins.