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This lecture covers advanced methods for human neuromodulation, focusing on the spinal cord. It describes neurotechnologies to modulate spinal cord activity, including non-invasive and invasive approaches, open-loop, and closed-loop systems. The lecture also explores clinical applications, such as spinal cord injury, and the physiology of the spinal cord. It delves into the organization of the spinal column, sensory and motor pathways, descending and ascending tracts, and the locomotor system. Additionally, it discusses spinal cord injury mechanisms, time course, and potential treatments. The lecture concludes with the use of non-invasive electrical spinal cord stimulation for rehabilitation and the modulation of motor output through dorsal root afferents.