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This lecture introduces the TILT course, a new interdisciplinary offering by UNIL/EPFL focusing on digital skills and sustainability. It covers case studies, discussions, guest speakers, and workshops on transversal skills, culminating in a second-semester project. The course emphasizes the importance of reproducibility, data construction, and ethical considerations in a quantified and connected world. It promotes collaborative interdisciplinary approaches, integrating statistics, humanities, social sciences, and journalism. The lecture also explores precision-driven health equity, algorithmic management's impact on work, and the relationship between artificial intelligence and the law.