Pharmacogenetics: Drug Response and Genetic Variability

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Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Genetic Variation in Populations

Explores genetic variation in populations, Hardy-Weinberg law, natural selection, and more.

Exact Simulation of Coupled Wright-Fisher Diffusions

Explores the exact simulation of coupled Wright-Fisher diffusions, covering population genetics, interacting loci networks, and diffusion challenges.

Natural Selection and Evolution

Explores natural selection, genetic variation, and evolutionary changes within populations, using examples like sickle cell anemia and flu virus evolution.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Cellular Communication and Metabolism: Energy Transformation Principles

Discusses cellular communication, metabolism, energy transformation, and the role of enzymes in biochemical reactions.

Pharmacodynamics: Ligand-Receptor Interactions and Drug Effects

Explores ligand-receptor interactions, drug effects, modulation mechanisms, and factors influencing drug responses.

Nuclear Receptors: Drug Targets

Explores nuclear receptors, their role in drug pharmacology, and physiological functions in adipose tissue and glucose homeostasis.

Hardy-Weinberg Equilibrium

Covers the Hardy-Weinberg equilibrium and its impact on allele frequencies in populations, emphasizing genetic drift and selective breeding.

Mendelian Randomization: Insights and Challenges

By Qingyuan Zhao delves into Mendelian randomization, exploring its history, challenges, and recent methods to handle pleiotropy.