Lecture

Total Synthesis of Discodermolide

In course

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Description

This lecture covers the total synthesis of Discodermolide, a potent immunosuppressive and cytotoxic compound isolated from a Caribbean deep-sea sponge. The synthesis involves various steps such as olefin metathesis, boron aldol reaction, Suzuki cross-coupling, and reduction. Strategies by Novartis and A. B. Smith are discussed, along with historical milestones in the development of this compound.

Instructors (2)

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Official source

https://mediaspace.epfl.ch/media/0_ird7gvu4

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