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This lecture covers the representation of binary numbers, including signed and unsigned integers, two's complement, and one's complement. It explains how to perform addition and subtraction operations on binary numbers, highlighting the use of two's complement for signed numbers. The lecture also delves into the interpretation of arithmetic flags and the instruction set of microcontrollers, focusing on assembler instructions and the execution of operations. Additionally, it discusses the organization of a microcontroller course, the architecture of microcontrollers, and the memory structure. Practical work and the development process from prototype to finished product are also explored.