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This lecture covers the concept of electrode polarization, including activation, concentration, and ohmic overpotentials, as well as the differences between polarizable and non-polarizable electrodes. It also discusses the electrochemical causes of tissue damage, the importance of biphasic pulses in electrotherapies, and methods to avoid tissue damage by controlling current flow. The lecture further explores the transient voltage and current responses to applied stimuli, the modeling of electrode-electrolyte interfaces, and the impact of motion artifacts on bio-potential measurements.