DNA Damage and Repair

This lecture covers the various types of DNA damage, such as replication errors and UV-induced damage, leading to mutations and cancer. It explains the mechanisms of repair, including nucleotide excision repair and mismatch repair, highlighting the importance of high-fidelity DNA synthesis and the role of DNA polymerase in proofreading. The lecture also discusses the consequences of DNA damage, the impact of ionizing radiation, and the significance of tumor suppressor genes in preventing cancer.