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This lecture focuses on calculating the standard enthalpy of formation of urea by considering the enthalpies of various chemical bonds and the standard enthalpies of sublimation of graphite and urea. The instructor explains the process step by step, using the given values for the enthalpies of formation of water and carbon dioxide. Through detailed calculations and explanations, the lecture demonstrates how to determine the enthalpy of formation of urea, highlighting the importance of bond energies and their impact on the overall enthalpy change. The lecture concludes by emphasizing the significance of average bond energies in obtaining the final value, which may differ from theoretical calculations.