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This lecture explores the link between obesity and socio-economic precarity using geospatial information to understand part of the obesity epidemic. It delves into the historical context of health-environment relationships, the concept of exposome in environmental health, and the collaboration between physicians and engineers. The lecture also covers the evolution of healthcare systems, individual-centered approaches, epidemiology, spatial epidemiology, and the use of geomedicine to study obesity and precarity. It discusses the Townsend Deprivation Index, genetic factors influencing obesity, and the importance of precision public health in addressing social inequalities in healthcare. The lecture concludes by highlighting the significance of geospatial analysis in public health policies and research.