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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the cellular mechanisms underlying synaptic plasticity, focusing on long-term potentiation (LTP) and long-term depression (LTD). It explains how LTP is induced by high-frequency stimulation and NMDA receptor activation, leading to postsynaptic cytosolic calcium increase and protein kinase activation. On the other hand, LTD is often induced by repetitive low-frequency stimulation and involves NMDA receptor activation and protein phosphatases. Additionally, spike timing-dependent plasticity (STDP) is discussed, highlighting the importance of precise timing in synaptic changes.