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This lecture explores the impact of early-life oxidative stress on lifespan and age-related diseases, focusing on the role of redox-regulated processes, reactive oxygen species, and H3K4me3 levels in C. elegans. The instructor discusses how maternal redox state and age affect offspring's redox state, lifespan, and gene expression, highlighting the interplay between oxidative stress, epigenetic changes, and longevity pathways.