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This lecture covers the control and regulation of microcirculation, including the determinants of ultrafiltration through the endothelium, the role of respiration in venous return, local and humoral control of blood flow by tissues, vasoactive mediators, pre-capillary sphincters, local autoregulation theory, long-term regulation, central regulation of the cardiovascular system, vascular receptors, and blood pressure control. It also discusses the adaptation to exercise, modulation of blood flow, and distribution of blood flow during exercise. Various concepts such as Reynolds number, laminar and turbulent flow, and the role of different mediators in blood flow control are explained.