This lecture covers the principles of catalytic asymmetric reactions in organic chemistry, focusing on Lewis and Brønsted acids activation of carbonyl and imines. Topics include LUMO activation, Lewis acid catalysis, and various types of reactions such as Aldol, Mannich, and Diels Alder. The instructor discusses the use of chiral catalysts, ligands, and the role of different nucleophiles in achieving high enantioselectivity.