This lecture covers the regulation of the cardiovascular system, focusing on the role of the sympathetic and parasympathetic systems, intracellular signaling, the cardiac cycle, the Frank-Starling law, determinants of cardiac output, cardiac activity regulation, vascular blood flow, determinants of vascular blood pressure, arterial resistance, compliance, and the measurement of arterial pressure. It also delves into the control of cardiac activity through autonomous control of frequency and force, the equations governing cardiovascular flow, the modulation of metabolism by calcium, and the intrinsic regulation of heart contractility through the Frank-Starling law.