COVID-19 Diagnostic Tools

This lecture covers the development of diagnostic tools for COVID-19, including high-throughput screening, genetics vs. pharmacological approaches, optogenetic tools, CRISPR diagnostics, and chemoproteomics. It delves into the biology of SARS-CoV2, viral replication, and transcription complex, as well as the interaction of the S-protein with host cells. The lecture also explores the challenges of human clinical trials for SARS-CoV2 inhibitors and the detection strategies for COVID-19, such as rt-RT-qPCR, antigen tests, RT-LAMP, and Cas13. Additionally, it discusses the pros and cons of different testing methods and the potential future screening technologies.