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This lecture focuses on functional ultrasound imaging (fUS) as a powerful tool to measure brain-wide vascular signals linked to neuronal activity. The instructor highlights recent technical advancements in fUS, demonstrating its potential in understanding the neural basis of behavior, including the modulation of brain-wide activity by arousal and internal states. The lecture also discusses the role of the noradrenergic system in this process. The speaker, Prof. Emilie Macé, shares insights from her research using fUS to address fundamental questions about brain-wide circuits underlying behavioral choices in health and psychiatric diseases.