Computational Cell Biology: Liquid-Liquid Phase Separation

This lecture delves into the computational exploration of cell biology, focusing on the phenomenon of liquid-liquid phase separation of proteins within cells. The slides discuss the inaccuracies in our mental picture of cellular functions, the role of biomolecular condensates in cellular matter, and the implications of phase separation in creating compositional gradients for various cellular functions. The lecture also covers the central dogma of molecular biology, the mechanical sensing and restructuring of the genome by nuclear condensates, and the experimental observations and simulations of biomolecular condensates. The instructor emphasizes the importance of simulations in understanding the mysterious nature of cellular mechanisms and the potential for generating novel insights into cell biology problems.