This lecture covers the process of downloading and interacting with single cell models, starting with importing Python packages for visualization and analysis, downloading a Neocortical Layer 5 Thick Tufted Pyramidal cell model, extracting the model files, compiling NEURON simulator mechanisms, and visualizing the cell morphology using NeuroM. The lecture also explains how to initialize the model by loading the 'init.hoc' file, create a cell with synapses, and inject a step current into the neuron's soma.