Selective Drug Targeting Mechanisms

This lecture covers the relevance of pharmacological strategies in targeting differences between microbes or cancer cells and normal host cells, including mechanisms like unique drug targets, selective inhibition of similar targets, and differences in therapeutic index. It also discusses the development of resistance to anti-infective drugs, the increase in tuberculosis incidence, and the impact of BCR-ABL mutations on chronic myeloid leukemia patients. Furthermore, it explores tyrosine kinase inhibitors for leukemia, drug toxicity, drug interactions, and toxicology studies during drug development.