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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
This lecture covers the design optimization of Snif-it's sensors, focusing on geometry, sequence of domains, spacing, and circular permutation, aiming to understand the molecular basis for changes in FRET ratio and the effective concentration of intra-molecular ligands. It also introduces semi-synthetic sensors for visualizing metabolite concentrations and LUCID's bioluminescent sensor proteins for drug monitoring, including the principles behind them and their applications in point-of-care therapeutic drug monitoring.