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This lecture introduces the data tools and brain atlases developed by the Allen Institute for Brain Science, focusing on genetic tools, brain connectivity, and the Allen Brain Atlas. It covers the parts of the brain, their connections, information processing, and disease mechanisms. The lecture explains the launch dates of various brain atlases, including the Mouse Brain Atlas and the Human Brain Atlas, emphasizing big science, open science, and team science approaches. It details the institute's computational models, emergent computations, and top-down signals for understanding brain function. The lecture also delves into the institute's approach to studying the brain, utilizing genetic tools, connection analysis, morphology, physiology, and molecular profiling to achieve an integrated understanding of brain properties.