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This lecture, presented by Claude Nicolier, a former ESA Astronaut and Honorary Professor at the Swiss Federal Institute of Technology, covers space mission design and operations. Nicolier shares insights from his experiences as an astronaut, including Earth orbits, rendezvous in space, interplanetary missions, and space environment. The course delves into astrodynamics, space propulsion, human spaceflight, space systems, spacewalking, robotics, and astronaut training, providing practical tools for understanding the physics and dynamics of space travel.