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This lecture aims to understand the physical basis of signal propagation in neurons, focusing on the setup of membrane potential, Nernst potential, and the coordination of pumps and channels. It explores the generation of electrical signals in cells, the establishment of transmembrane potential, and the modeling of voltage-gated ion channels. The lecture delves into the equilibrium state of cells, the energy needed for ionic gradients, and the role of ion channels in muscle contraction. Additionally, it discusses the modeling of the membrane as an electrical circuit, including capacitance and the change in membrane potential. Overall, the lecture provides insights into the fundamental principles of electricity in cells.