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This lecture discusses the impact of the physical environment on health, emphasizing the importance of clean water, sanitation, hygiene, and air quality. It explores how environmental factors contribute to diseases and injuries, such as waterborne illnesses, malnutrition, respiratory infections, and physical traumas, particularly in African urban settings. The lecture also addresses the challenges of inadequate waste management, pollution, and the health risks associated with using biomass fuels for cooking. Strategies to mitigate these risks, improve living conditions, and prevent diseases are highlighted, underscoring the need for sustainable environmental health interventions.