This lecture covers irreversible processes and transport phenomena, focusing on heat, pressure, and chemical potential differences. It discusses temperature differences in isolated systems, state variables, thermal conductivity, and the second principle of heat transfer. It also explores pressure differences in isolated systems, thermal equilibrium, and the thermoelastic coefficient of friction. Moreover, it delves into chemical potential differences, Fick diffusion coefficient, wall area, and the transfer of matter based on chemical potential gradients.