This lecture explores the cause and effect chain in the context of climate change, focusing on the evaluation of life cycle impacts. It covers the emission of greenhouse gases, disruption of radiation balance, global temperature rise, sea level increase, and various environmental mechanisms. The conceptual cause and effect chain of climate change is discussed, including radiative forcing, temperature, primary production, biomes, forest fires, malnutrition, extreme weather events, infectious diseases, heatwaves, ecosystem quality, and human health.