This lecture covers the development and applications of Micro-ElectroMechanical Systems (MEMS), focusing on the work of Prof. Gijs at EPFL. It discusses the fabrication process, challenges, and solutions in creating MEMS devices, such as microfluidic circuits and micro-optical systems. The lecture also delves into the importance of ion channels in biological functions, the patch clamp technique for measuring ion channel activity, and the search for new drugs targeting specific ion channels. Additionally, it explores the integration of PDMS coatings and gaskets in microfluidic systems for improved cell positioning and electrical measurements on single living cells.