This lecture covers the development of intelligent, wireless neural interfaces for neuroprosthetics, focusing on closed-loop systems that provide personalized treatment autonomously. Topics include deep brain stimulation, implantable neurostimulators, simultaneous sensing and processing, and the use of ultrasound and optogenetics. The presentation showcases cutting-edge technologies such as scaled neuromodulation systems, MEMS mirrors, and holographic optogenetics. The instructor discusses the challenges and advancements in achieving precise and efficient neural stimulation, as well as the potential applications in seizure detection and neural recording. The lecture also explores the integration of neuromodulation devices with wireless communication and the future prospects of neuroprosthetic technologies.