This lecture covers the purpose and techniques of CMOS for extracellular recording, high spatial resolution interfacing philosophies, neural tissue stimulation, ease-of-use, and commercialization. It delves into the evaluation criteria, parameters, and features of high-resolution neural tissue imaging chips, CMOS MEA with 11k metal electrodes, neural activity imagers with 16k sites/channels, and bidirectional chips with 32k sites. The lecture also presents a two-way interfacing experiment with a single snail neuron, showcasing intracellular and extracellular voltage measurements.