This lecture covers the mechanisms of relaxation in biomedical imaging, focusing on the return to equilibrium of transverse and longitudinal magnetization, the impact of molecular dynamics, and the causes of loss of transverse magnetization. The instructor explains how Brownian motion creates fluctuating magnetic fields, leading to T1 and T2 relaxation processes, and discusses the historical context of spin-spin relaxation. The lecture also delves into the role of molecular fluctuations, energy transfer, and the re-establishment of Boltzmann distribution. Practical implications for tissue water relaxation times are highlighted.