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This lecture focuses on the practical observation of a histological section of a colon, highlighting the four tissue layers that make up the digestive system. The instructor explains the characteristics of each layer, such as the mucosa, submucosa, muscularis, and adventitia, and emphasizes the importance of recognizing the epithelium, lamina propria, and muscularis mucosae. The lecture also covers the presence of lymphoid nodules, blood vessels, and the differences between the longitudinal and circular muscle layers. Additionally, the instructor discusses the plexus of Auerbach, a network of neurons located between the muscle layers in the digestive system.